Renal failure or Kidney failure is where your kidneys are unable to filter waste from your blood. Kidneys also produce hormones which keep your body and bones strong. Treatment options for renal failure have traditionally been treating underlying disease causes such as diabetes and high blood pressure, or in other cases, dialysis or kidney transplant.
Current Research Studies
“Mesenchymal Stromal Cells Improve Renovascular Function in Polycystic Kidney Disease” This study examined the potential use of Adult Mesenchymal Stem Cells to restore renal structure and function in Polycystic Kidney Disease, which is a common cause of end stage renal failure. This was an animal study using rats. Bone Marrow Derived Mesenchymal Stem Cells were injected into the kidney. 4 weeks after treatment, Mesenchymal Stem Cells improved density of veins and arteries, as well as, renal function. The study shows that stem cell therapy is an effective and safe approach for renal failure patients. (October 2014).
“Autologous Bone Marrow Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection after Renal Transplantation: Results of a Phase I Study” This study investigated safety and effectiveness of treating patients with Bone Marrow Derived Mesenchymal Stem Cells following renal failure. 6 patients received 2 IV infusions of Mesenchymal Stem Cells. Follow up was done 6 months after the second infusion. Results indicated that infusions were well-tolerated, no adverse events were reported, and patients had beneficial responses to the stem cell therapy. (January 2013).
“Induction Therapy with Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants: A Randomized Controlled Trial” This study researched treating kidney transplant patients with induction therapy or using Adult Mesenchymal Stem Cell therapy to reduce rejection rates. The study concluded that using Adult Mesenchymal Stem Cell therapy resulted in a lower incidence of rejection, a decreased risk of infection, and better kidney function at 1 year post kidney transplant. (March 2012).